Ontology highlight
ABSTRACT:
SUBMITTER: Masujin K
PROVIDER: S-EPMC4768002 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Masujin Kentaro K Orrú Christina D CD Miyazawa Kohtaro K Groveman Bradley R BR Raymond Lynne D LD Hughson Andrew G AG Caughey Byron B
Journal of clinical microbiology 20160106 3
Prion diseases of cattle include the classical bovine spongiform encephalopathy (C-BSE) and the atypical H-type BSE (H-BSE) and L-type BSE (L-BSE) strains. Although the C- and L-BSE strains can be detected and discriminated by ultrasensitive real-time quaking-induced conversion (RT-QuIC) assays, no such test has yet been described for the detection of H-BSE or the discrimination of each of the major bovine prion strains. Here, we demonstrate an RT-QuIC assay for H-BSE that can detect as little a ...[more]