Ontology highlight
ABSTRACT:
SUBMITTER: Leng RX
PROVIDER: S-EPMC4768161 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Leng Rui-Xue RX Pan Hai-Feng HF Liu Juan J Yang Xiao-Ke XK Zhang Chao C Tao Sha-Sha SS Wang De-Guang DG Li Xiao-Mei XM Li Xiang-Pei XP Yang Wanling W Ye Dong-Qing DQ
Scientific reports 20160226
TBX21 recode T-bet which is an important transcription factor that drives the Th1 immune response primarily by promoting expression of the interferon-gamma (IFNG) gene. Recent studies have shown that genetic variants in TBX21 and IFNG are connected with risk of systemic lupus erythematosus (SLE). The aim of the present study was to replicate these genetic associations with SLE in Anhui Chinese population. Genotyping of 3 variants (rs4794067 in TBX21, rs2069705 and rs2069718 in IFNG) was performe ...[more]