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Association Study Between SLC15A4 Polymorphisms and Haplotypes and Systemic Lupus Erythematosus in a Han Chinese Population.

ABSTRACT: The gene SLC15A4 (solute carrier family 15 [oligopeptide transporter], member 4) has been reported as contributing to the pathogenesis of systemic lupus erythematosus (SLE). We performed a case-control replication study to investigate further the association between single-nucleotide polymorphisms (SNPs) in the SLC15A4 gene and systemic SLE in a Han Chinese population.In Han Chinese SLE patients and healthy individuals (n?=?355, 375, respectively), 18 SNPs in the SLC15A4 gene were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and TaqMan SNP genotyping assays. Analyses of allele frequencies and genotypes using codominant, dominant, and recessive models were conducted, as well as a linkage disequilibrium analysis. P values?

SUBMITTER: Zhang M

PROVIDER: S-EPMC4991581 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Association Study Between SLC15A4 Polymorphisms and Haplotypes and Systemic Lupus Erythematosus in a Han Chinese Population.

Zhang Mingwang M Chen Fangru F Zhang Dongmei D Zhai Zhifang Z Hao Fei F

Genetic testing and molecular biomarkers 20160630 8

<h4>Objective</h4>The gene SLC15A4 (solute carrier family 15 [oligopeptide transporter], member 4) has been reported as contributing to the pathogenesis of systemic lupus erythematosus (SLE). We performed a case-control replication study to investigate further the association between single-nucleotide polymorphisms (SNPs) in the SLC15A4 gene and systemic SLE in a Han Chinese population.<h4>Methods</h4>In Han Chinese SLE patients and healthy individuals (n = 355, 375, respectively), 18 SNPs in th ...[more]

PMID: 27362648

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