Ontology highlight
ABSTRACT:
SUBMITTER: Kuijk EW
PROVIDER: S-EPMC4768167 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kuijk Ewart W EW Rasmussen Shauna S Blokzijl Francis F Huch Meritxell M Gehart Helmuth H Toonen Pim P Begthel Harry H Clevers Hans H Geurts Aron M AM Cuppen Edwin E
Scientific reports 20160226
The rat is an important model for liver regeneration. However, there is no in vitro culture system that can capture the massive proliferation that can be observed after partial hepatectomy in rats. We here describe the generation of rat liver stem cell lines. Rat liver stem cells, which grow as cystic organoids, were characterized by high expression of the stem cell marker Lgr5, by the expression of liver progenitor and duct markers, and by low expression of hepatocyte markers, oval cell markers ...[more]