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Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle.

ABSTRACT: Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last round of vaccination almost half the cattle aged < 24 months remain unvaccinated. Only 50% of all cattle would have received > 1 vaccine dose in their life with the last dose given ? 6 months ago. Five months after the last round of vaccination two-thirds of cattle would have low antibody titres (< 70% protection threshold). Giving a two-dose primary vaccination course reduces the proportion of 6-12 month old cattle with low titres by 20-30%. Biannual mass vaccination of cattle leaves significant immunity gaps and over-reliance on vaccine protection should be avoided. Using more effective vaccines and vaccination strategies will increase population immunity, however, the extent to which FMD can be controlled by vaccination alone without effective biosecurity remains uncertain.

SUBMITTER: Knight-Jones TJ

PROVIDER: S-EPMC4768268 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle.

Knight-Jones T J D TJ Gubbins S S Bulut A N AN Stärk K D C KD Pfeiffer D U DU Sumption K J KJ Paton D J DJ

Scientific reports 20160226

Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last ...[more]

PMID: 26916556

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Project description:In South Korea, domestic cattle, pigs, and goats were subjected to mandatory foot-and-mouth disease (FMD) vaccination and year-round serosurveillance since 2011. In 2020, approximately USD 95 million was spent solely for FMD vaccine purchase for 59 million livestock, and 1.25 million samples were tested to estimate the population immunity and demonstrate the absence of virus circulation. As the FMD vaccination program was revised in 2018, the post-vaccination monitoring (PVM) was designed to evaluate the effectiveness of the vaccine program of three vaccines approved for routine use. To this end, monitoring post-vaccination immunity has been conducted by collecting 35,626 serum samples at 28 days post-vaccination following regular national vaccinations, which were carried out in April and in October in 2020. The design of the serological test for PVM was specially targeted at particular livestock groups, including dairy cattle, goats, and beef cattle aged 6-12 months, which were generally estimated to have a low expected seroprevalence. The risk factors had also been identified, considering the increased likelihood of infection in a particular location, herd size, and husbandry system applied in a targeted sample collection. Serum sample collection and SP-O and NSP antibody tests were performed by local veterinary laboratories using commercially available ELISAs. The current FMD vaccination program, which was performed twice a year following the regimen of primary vaccination and boost, resulted in over 80% population immunity. The seroprevalence monitored after the vaccination in fall was higher than the one studied in spring except in pigs. It was demonstrated that the seroprevalence of risk-based targeted samples ranged from 93.8 to 100% in cattle, 63.2 to 100% in pigs, and 20.0 to 100% in goats. Of note is the area near the North Korean borders which showed a relatively low seroprevalence among the targeted regions, and no NSP sero-positive reactor was detected in this region. When subpopulation immunity at the individual level was assessed, the seroprevalence in young cattle stock was slightly lower (95.8%) than that of adults (98.4%). In conclusion, the FMD vaccination campaign has been successfully implemented in Korea, and the PVM can be a supplementary program for massive routine surveillance in terms of providing timely information needed both to estimate population immunity and to properly target "risk-based surveillance."

Project description:Biannual mass vaccination is a routinely applied foot-and-mouth disease (FMD) control strategy in Turkey. However, because biannual mass vaccination may leave significant immunity gaps, this strategy may cause economic losses because of possible FMD infections. In high-risk areas-such as border cities, it was suggested by the government to increase the vaccination intervals in order to decrease the FMD infection risk. This study analyses and compares the economic effects of a biannual mass vaccination regime and vaccination every 4 months as an alternative strategy in border cities by using partial budgeting approach. Biannual mass vaccination was used as a baseline scenario. Data on the impact of FMD on animal health and production parameters for 2018 were obtained from the OIE-WAHIS system and complemented by literature data and expert opinion. In the partial budgeting model, weight loss was considered as a major loss of income because majority of the farming systems are based on cattle fattening in the border cities of Turkey. Results revealed that the net economic impact, which is the benefit that exceeds the losses and costs of increasing the frequency of vaccination, is 76.4 TL ($15.9) per cattle. The sensitivity analysis showed that average body weight and weight losses when infected had more effect on net impact changes than market prices. The lower and upper FMD incidence variability resulted in 19.2 TL ($4) and 190.8 TL ($39.6) of net impact per cattle, respectively. The new FMD control strategy would make a total net economic impact of 5,274,836 TL ($1,094,250) for a population of 800,970 fattening cattle in border cities. The results of this study indicated that intense FMD control strategies may be more cost effective than the current control strategies, especially in high-risk areas. Future studies with more comprehensive epidemiological and economic data must be conducted to analyze and compare alternative FMD control strategies in Turkey.

Dataset Information

Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle.

Publications

Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle.

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