Ontology highlight
ABSTRACT:
SUBMITTER: Cornella J
PROVIDER: S-EPMC4768290 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cornella Josep J Edwards Jacob T JT Qin Tian T Kawamura Shuhei S Wang Jie J Pan Chung-Mao CM Gianatassio Ryan R Schmidt Michael M Eastgate Martin D MD Baran Phil S PS
Journal of the American Chemical Society 20160209 7
A new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with aryl zinc reagents under Ni-catalysis. The success of this reaction hinges on the unique use of redox-active esters that allow one to employ such derivatives as alkyl halides surrogates. The chemistry exhibits broad substrate scope and features a high degree of practicality. The simple procedure and extremely inexpensive nature of both the substrates and pre-catalyst (NiCl2·6H2O, ca. $9.5/mol) bo ...[more]