Ni/Co-Catalyzed Homo-Coupling of Alkyl Tosylates.

ABSTRACT: A direct reductive homo-coupling of alkyl tosylates has been developed by employing a combination of nickel and nucleophilic cobalt catalysts. A single-electron-transfer-type oxidative addition is a pivotal process in the well-established nickel-catalyzed coupling of alkyl halides. However, the method cannot be applied to the homo-coupling of ubiquitous alkyl tosylates due to the high-lying ?*(C-O) orbital of the tosylates. This paper describes a Ni/Co-catalyzed protocol for the activation of alkyl tosylates on the construction of alkyl dimers under mild conditions.

SUBMITTER: Komeyama K 

PROVIDER: S-EPMC6515247 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature