Ontology highlight
ABSTRACT:
SUBMITTER: Hansen SG
PROVIDER: S-EPMC4769032 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160121 6274
Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in the regulation of natural killer (NK) cells. We found that vaccinating rhesus macaques with rhesus cytomegalovirus vectors in which genes Rh157.5 and Rh157.4 are deleted results in MHC-E-restricted presentation of highly varied peptide epitopes to CD8αβ(+) T cells, at ~4 distinct epitopes per 100 amino acids in all te ...[more]