Dataset Information

In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study.

ABSTRACT:

Purpose

To establish that a magnetic device designed for intravascular use can bind small iron particles in physiologic flow models.

Materials and methods

Uncoated iron oxide particles 50-100 nm and 1-5 µm in size were tested in a water flow chamber over a period of 10 minutes without a magnet (ie, control) and with large and small prototype magnets. These same particles and 1-µm carboxylic acid-coated iron oxide beads were likewise tested in a serum flow chamber model without a magnet (ie, control) and with the small prototype magnet.

Results

Particles were successfully captured from solution. Particle concentrations in solution decreased in all experiments (P < .05 vs matched control runs). At 10 minutes, concentrations were 98% (50-100-nm particles in water with a large magnet), 97% (50-100-nm particles in water with a small magnet), 99% (1-5-µm particles in water with a large magnet), 99% (1-5-µm particles in water with a small magnet), 95% (50-100-nm particles in serum with a small magnet), 92% (1-5-µm particles in serum with a small magnet), and 75% (1-µm coated beads in serum with a small magnet) lower compared with matched control runs.

Conclusions

This study demonstrates the concept of magnetic capture of small iron oxide particles in physiologic flow models by using a small wire-mounted magnetic filter designed for intravascular use.

SUBMITTER: Mabray MC

PROVIDER: S-EPMC4769113 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Publications

In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study.

Mabray Marc C MC Lillaney Prasheel P Sze Chia-Hung CH Losey Aaron D AD Yang Jeffrey J Kondapavulur Sravani S Liu Derek D Saeed Maythem M Patel Anand A Cooke Daniel D Jun Young-Wook YW El-Sayed Ivan I Wilson Mark M Hetts Steven W SW

Journal of vascular and interventional radiology : JVIR 20151222 3

<h4>Purpose</h4>To establish that a magnetic device designed for intravascular use can bind small iron particles in physiologic flow models.<h4>Materials and methods</h4>Uncoated iron oxide particles 50-100 nm and 1-5 µm in size were tested in a water flow chamber over a period of 10 minutes without a magnet (ie, control) and with large and small prototype magnets. These same particles and 1-µm carboxylic acid-coated iron oxide beads were likewise tested in a serum flow chamber model without a m ...[more]

PMID: 26706187

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Dataset Information

In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study.

Purpose

Materials and methods

Results

Conclusions

Publications

In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study.

Similar Datasets

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