Intraarterial Microdosing: A Novel Drug Development Approach, Proof-of-Concept PET Study in Rats.

ABSTRACT:

Unlabelled

Intraarterial microdosing (IAM) is a novel drug development approach combining intraarterial drug delivery and microdosing. We aimed to demonstrate that IAM leads to target exposure similar to that of systemic full-dose administration but with minimal systemic exposure. IAM could enable the safe, inexpensive, and early study of novel drugs at the first-in-human stage and the study of established drugs in vulnerable populations.

Methods

Insulin was administered intraarterially (ipsilateral femoral artery) or systemically to 8 CD IGS rats just before blood sampling or 60-min (18)F-FDG uptake PET imaging of ipsilateral and contralateral leg muscles (lateral gastrocnemius) and systemic muscles (spinotrapezius). The (18)F-FDG uptake slope analysis was used to compare t

SUBMITTER: Burt T 

PROVIDER: S-EPMC4767259 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature