Ontology highlight
ABSTRACT:
SUBMITTER: Walter M
PROVIDER: S-EPMC4769179 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Walter Marius M Teissandier Aurélie A Pérez-Palacios Raquel R Bourc'his Déborah D
eLife 20160127
DNA methylation is extensively remodeled during mammalian gametogenesis and embryogenesis. Most transposons become hypomethylated, raising the question of their regulation in the absence of DNA methylation. To reproduce a rapid and extensive demethylation, we subjected mouse ES cells to chemically defined hypomethylating culture conditions. Surprisingly, we observed two phases of transposon regulation. After an initial burst of de-repression, various transposon families were efficiently re-silen ...[more]