Ontology highlight
ABSTRACT:
SUBMITTER: Singer ZS
PROVIDER: S-EPMC4104113 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Singer Zakary S ZS Yong John J Tischler Julia J Hackett Jamie A JA Altinok Alphan A Surani M Azim MA Cai Long L Elowitz Michael B MB
Molecular cell 20140701 2
Cell populations can be strikingly heterogeneous, composed of multiple cellular states, each exhibiting stochastic noise in its gene expression. A major challenge is to disentangle these two types of variability and to understand the dynamic processes and mechanisms that control them. Embryonic stem cells (ESCs) provide an ideal model system to address this issue because they exhibit heterogeneous and dynamic expression of functionally important regulatory factors. We analyzed gene expression in ...[more]