Ontology highlight
ABSTRACT:
SUBMITTER: Larsen MT
PROVIDER: S-EPMC4769556 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Larsen Maja Thim MT Kuhlmann Matthias M Hvam Michael Lykke ML Howard Kenneth A KA
Molecular and cellular therapies 20160227
The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attrac ...[more]