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Albumin-based drug delivery: harnessing nature to cure disease.

ABSTRACT: The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform.

SUBMITTER: Larsen MT

PROVIDER: S-EPMC4769556 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Albumin-based drug delivery: harnessing nature to cure disease.

Larsen Maja Thim MT Kuhlmann Matthias M Hvam Michael Lykke ML Howard Kenneth A KA

Molecular and cellular therapies 20160227

The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attrac ...[more]

PMID: 26925240

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