Ontology highlight
ABSTRACT:
SUBMITTER: Hackett MJ
PROVIDER: S-EPMC3617480 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Hackett Michael J MJ Joolakanti Shyamsunder S Hartranft Megan E ME Guley Patrick C PC Cho Moo J MJ
Journal of pharmaceutical sciences 20120606 9
Paclitaxel (PTX) is a potent chemotherapy for many cancers but it suffers from very poor solubility. Consequently, the TAXOL formulation uses copious amounts of the surfactant Cremophor EL to solubilize the drug for injection, resulting in severe hypersensitivity and neutropenia. In contrast to Cremophor EL, presented is a way to solubilize PTX by conjugation of a dicarboxylic fatty acid for specific binding to the ubiquitous protein, serum albumin. The conjugation chemistry was simplified to a ...[more]