Ontology highlight
ABSTRACT:
SUBMITTER: Mardilovich K
PROVIDER: S-EPMC4770715 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Mardilovich Katerina K Baugh Mark M Crighton Diane D Kowalczyk Dominika D Gabrielsen Mads M Munro June J Croft Daniel R DR Lourenco Filipe F James Daniel D Kalna Gabriella G McGarry Lynn L Rath Oliver O Shanks Emma E Garnett Mathew J MJ McDermott Ultan U Brookfield Joanna J Charles Mark M Hammonds Tim T Olson Michael F MF
Oncotarget 20151101 36
The actin and microtubule cytoskeletons are critically important for cancer cell proliferation, and drugs that target microtubules are widely-used cancer therapies. However, their utility is compromised by toxicities due to dose and exposure. To overcome these issues, we characterized how inhibition of the actin and microtubule cytoskeleton regulatory LIM kinases could be used in drug combinations to increase efficacy. A previously-described LIMK inhibitor (LIMKi) induced dose-dependent microtub ...[more]