Ontology highlight
ABSTRACT:
SUBMITTER: Cherry AE
PROVIDER: S-EPMC6557680 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cherry Allison E AE Vicente Juan Jesus JJ Xu Cong C Morrison Richard S RS Ong Shao-En SE Wordeman Linda L Stella Nephi N
Glia 20190506 8
GPR124 is involved in embryonic development and remains expressed by select organs. The importance of GPR124 during development suggests that its aberrant expression might participate in tumor growth. Here we show that both increases and decreases in GPR124 expression in glioblastoma cells reduce cell proliferation by differentially altering the duration mitotic progression. Using mass spectrometry-based proteomics, we discovered that GPR124 interacts with ch-TOG, a known regulator of both micro ...[more]