Ontology highlight
ABSTRACT:
SUBMITTER: Zhao GX
PROVIDER: S-EPMC4770749 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Zhao Gao-Xiang GX Xu Li-Hui LH Pan Hao H Lin Qiu-Ru QR Huang Mei-Yun MY Cai Ji-Ye JY Ouyang Dong-Yun DY He Xian-Hui XH
Oncotarget 20151101 36
Previously we reported that valproic acid (VPA) acts in synergy with GOS to enhance cell death in human DU145 cells. However, the underlying mechanism remains elusive. In this study, we observed that such synergistic cytotoxicity of GOS and VPA could be extended to human A375, HeLa, and PC-3 cancer cells. GOS and VPA co-treatment induced robust apoptosis as evidenced by caspase-8/-9/-3 activation, PARP cleavage, and nuclear fragmentation. GOS and VPA also markedly decreased cyclin A2 protein exp ...[more]