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MiR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma.

ABSTRACT: Previous studies showed that miR-454 acted as an oncogene or tumor suppressor in cancer. However, its function in HCC remains unknown. In this study, we found that miR-454 expression was upregulated in HCC cell lines and tissues. Knockdown of miR-454 inhibited HCC cell proliferation and invasion and epithelial mesenchymal transition (EMT), whereas overexpression of miR-454 promoted HCC cell proliferation and invasion and EMT. Furthermore, we identified the CHD5 as a direct target of miR-454. CHD5 was downregulated in HCC tissues and cell lines and the expression level of CHD5 was inversely correlated with the expression of miR-454 in HCC tissues. In addition, knockdown of miR-454 inhibited the growth of HepG2-engrafted tumors in vivo. Taken together, these results indicated that miR-454 functioned as an oncogene in HCC.

SUBMITTER: Yu L

PROVIDER: S-EPMC4770768 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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miR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma.

Yu Lei L Gong Xuejun X Sun Lei L Yao Hong H Lu Baoling B Zhu Liying L

Oncotarget 20151101 36

Previous studies showed that miR-454 acted as an oncogene or tumor suppressor in cancer. However, its function in HCC remains unknown. In this study, we found that miR-454 expression was upregulated in HCC cell lines and tissues. Knockdown of miR-454 inhibited HCC cell proliferation and invasion and epithelial mesenchymal transition (EMT), whereas overexpression of miR-454 promoted HCC cell proliferation and invasion and EMT. Furthermore, we identified the CHD5 as a direct target of miR-454. CHD ...[more]

PMID: 26287602

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