Immunogenicity and protective efficacy of Clostridium difficile spore proteins.
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ABSTRACT:
SUBMITTER: Ghose C
PROVIDER: S-EPMC4770901 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Immunogenicity and protective efficacy of Clostridium difficile spore proteins.
Ghose Chandrabali C Eugenis Ioannis I Edwards Adrianne N AN Sun Xingmin X McBride Shonna M SM Ho David D DD
Anaerobe 20151211
Clostridium difficile is a spore-forming, anaerobic, Gram-positive organism that is the leading cause of antibiotic-associated infectious diarrhea, commonly known as C. difficile infection (CDI). C. difficile spores play an important role in the pathogenesis of CDI. Spore proteins, especially those that are surface-bound may play an essential role in the germination, colonization and persistence of C. difficile in the human gut. In our current study, we report the identification of two surface-b ...[more]
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