Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.
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ABSTRACT:
SUBMITTER: Stasiak M
PROVIDER: S-EPMC4773148 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.
Stasiak Marta M Boncela Joanna J Perreau Corinne C Karamanou Konstantina K Chatron-Colliet Aurore A Proult Isabelle I Przygodzka Patrycja P Chakravarti Shukti S Maquart François-Xavier FX Kowalska M Anna MA Wegrowski Yanusz Y Brézillon Stéphane S
PloS one 20160301 3
Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in ...[more]
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