Ontology highlight
ABSTRACT: Background
To investigate the efficacy, safety, and tolerability of weekly docetaxel treatment in advanced non-small cell lung cancer (NSCLC) patients in Korea.Methods
This prospective observational study included Korean advanced NSCLC patients with Eastern Cooperative Oncology Group performance status <2 who received weekly monotherapy of docetaxel at a dose determined by the physician. Efficacy measurements included tumor response rate, overall survival (OS), progression-free survival, and one-year survival rate. Safety was analyzed through recorded incidences of adverse events (AEs), serious adverse events (SAEs), deaths, and other related safety parameters, along with their toxicity grades.Results
Of 274 patients analyzed, one patient achieved a complete response and 42 partial responses; thus, the overall response rate was 15.7%. The OS rate at baseline and at one-year follow-up was 38.3% and 33.8%, respectively. AEs were reported in 229 (83.6%) patients. The most frequently reported hematologic AE of grade ?3 was a decrease in neutrophils, with 6.6% of the patients developing neutropenia. In non-hematologic AEs of grade ?3, the most common were infection with unknown absolute neutrophil count and death not associated with Common Terminology Criteria for Adverse Events (CTCAE) (4.7% each). The most common SAE reported was death, not associated with CTCAE (7.3%).Conclusions
In Korean patients, the weekly regimen of docetaxel monotherapy was safe and efficacious against advanced NSCLC.
SUBMITTER: Lim SM
PROVIDER: S-EPMC4773308 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Lim Sun Min SM Park Byeong Bae BB Park Keun-Chil KC Kim Hoon-Kyo HK Lee Jong Seok JS Bae Sung Hwa SH Lee Seung-Sei SS Kang Jin-Hyoung JH Park Se-Hoon SH Lee Gyeong-Won GW Lee Hyo-Rac HR Seo Jae Hong JH Kim Yong Tae YT Yang Sung Hyun SH Kim Joo-Hang JH
Thoracic cancer 20151101 2
<h4>Background</h4>To investigate the efficacy, safety, and tolerability of weekly docetaxel treatment in advanced non-small cell lung cancer (NSCLC) patients in Korea.<h4>Methods</h4>This prospective observational study included Korean advanced NSCLC patients with Eastern Cooperative Oncology Group performance status <2 who received weekly monotherapy of docetaxel at a dose determined by the physician. Efficacy measurements included tumor response rate, overall survival (OS), progression-free s ...[more]