Hypothalamic leptin action is mediated by histone deacetylase 5.
Ontology highlight
ABSTRACT:
SUBMITTER: Kabra DG
PROVIDER: S-EPMC4773494 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Hypothalamic leptin action is mediated by histone deacetylase 5.
Kabra Dhiraj G DG Pfuhlmann Katrin K García-Cáceres Cristina C Schriever Sonja C SC Casquero García Veronica V Kebede Adam Fiseha AF Fuente-Martin Esther E Trivedi Chitrang C Heppner Kristy K Uhlenhaut N Henriette NH Legutko Beata B Kabra Uma D UD Gao Yuanqing Y Yi Chun-Xia CX Quarta Carmelo C Clemmensen Christoffer C Finan Brian B Müller Timo D TD Meyer Carola W CW Paez-Pereda Marcelo M Stemmer Kerstin K Woods Stephen C SC Perez-Tilve Diego D Schneider Robert R Olson Eric N EN Tschöp Matthias H MH Pfluger Paul T PT
Nature communications 20160229
Hypothalamic leptin signalling has a key role in food intake and energy-balance control and is often impaired in obese individuals. Here we identify histone deacetylase 5 (HDAC5) as a regulator of leptin signalling and organismal energy balance. Global HDAC5 KO mice have increased food intake and greater diet-induced obesity when fed high-fat diet. Pharmacological and genetic inhibition of HDAC5 activity in the mediobasal hypothalamus increases food intake and modulates pathways implicated in le ...[more]
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