Ontology highlight
ABSTRACT:
SUBMITTER: Kabra DG
PROVIDER: S-EPMC4773494 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160229
Hypothalamic leptin signalling has a key role in food intake and energy-balance control and is often impaired in obese individuals. Here we identify histone deacetylase 5 (HDAC5) as a regulator of leptin signalling and organismal energy balance. Global HDAC5 KO mice have increased food intake and greater diet-induced obesity when fed high-fat diet. Pharmacological and genetic inhibition of HDAC5 activity in the mediobasal hypothalamus increases food intake and modulates pathways implicated in le ...[more]