Ontology highlight
ABSTRACT:
SUBMITTER: Lhomme S
PROVIDER: S-EPMC4775994 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Lhomme Sebastien S Kamar Nassim N Nicot Florence F Ducos Jacques J Bismuth Michael M Garrigue Valerie V Petitjean-Lecherbonnier Joelle J Ollivier Isabelle I Alessandri-Gradt Elodie E Goria Odile O Barth Heidi H Perrin Peggy P Saune Karine K Dubois Martine M Carcenac Romain R Lefebvre Caroline C Jeanne Nicolas N Abravanel Florence F Izopet Jacques J
Antimicrobial agents and chemotherapy 20151228 3
Hepatitis E virus (HEV) can lead to chronic infection in solid-organ transplant patients. Ribavirin is efficient for treatment of chronically infected patients. Recently, the1634R mutation in the HEV polymerase has been associated with treatment failure. However, it is unclear if this mutation can be used as a prognostic marker of treatment outcome. We studied the prevalence of the 1634R mutation in the HEV polymerase of patients starting ribavirin therapy, the influence of the 1634R variants on ...[more]