Dataset Information

Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.

ABSTRACT:

Background

Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown.

Methods

In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (eGFR [CKD-EPI formula]) and stage of chronic kidney disease (CKD [KDOQI stages 2-3]) with inactive desphospho-uncarboxylated MGP (dp-ucMGP), using multivariable linear and logistic regression.

Results

Among Flemish and white and black Africans, between-group differences in eGFR (90, 100 and 122 mL/min/1.73 m(2)), dp-ucMGP (3.7, 6.5 and 3.2 ?g/L), and CKD prevalence (53.5, 28.7 and 10.5%) were significant, but associations of eGFR with dp-ucMGP did not differ among ethnicities (P ? 0.075). For a doubling of dp-ucMGP, eGFR decreased by 1.5 (P = 0.023), 1.0 (P = 0.56), 2.8 (P = 0.0012) and 2.1 (P < 0.0001) mL/min/1.73 m(2) in Flemish, white Africans, black Africans and all participants combined; the odds ratios for moving up one CKD stage were 1.17 (P = 0.033), 1.03 (P = 0.87), 1.29 (P = 0.12) and 1.17 (P = 0.011), respectively.

Interpretation

In the general population, eGFR decreases and CKD risk increases with higher dp-ucMGP, a marker of VK deficiency. These findings highlight the possibility that VK supplementation might promote renal health.

SUBMITTER: Wei FF

PROVIDER: S-EPMC4776057 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Publications

Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.

Wei Fang-Fei FF Drummen Nadja E A NE Schutte Aletta E AE Thijs Lutgarde L Jacobs Lotte L Petit Thibaut T Yang Wen-Yi WY Smith Wayne W Zhang Zhen-Yu ZY Gu Yu-Mei YM Kuznetsova Tatiana T Verhamme Peter P Allegaert Karel K Schutte Rudolph R Lerut Evelyne E Evenepoel Pieter P Vermeer Cees C Staessen Jan A JA

EBioMedicine 20160113

<h4>Background</h4>Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown.<h4>Methods</h4>In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (eGFR [CKD-EPI formula]) and stage of chronic kidney disease (CKD [KDOQI stages 2-3]) with inactive desphospho-uncarboxylated MGP (dp-ucMGP), using multivariable linear ...[more]

PMID: 26981580

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Dataset Information

Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.

Background

Methods

Results

Interpretation

Publications

Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.

Similar Datasets

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