Unknown

Dataset Information

0

Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells.


ABSTRACT: Influenza virus infection has a significant impact on public health, since it is a major cause of morbidity and mortality. It is not well-known whether influenza virus infection affects cell death and human immunodeficiency virus (HIV)-1 replication in HIV-1-infected patients. Using a lymphoma cell line, Jurkat, we examined the in vitro effects of pandemic influenza A (H1N1) virus (pH1N1) infection on cell death and HIV-1 RNA production in infected cells. We found that pH1N1 infection increased apoptotic cell death through Fas and Bax-mediated pathways in HIV-1-infected Jurkat cells. Infection with pH1N1 virus could promote HIV-1 RNA production by activating host transcription factors including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B), nuclear factor of activated T-cells (NFAT) and activator protein 1 (AP-1) through mitogen-activated protein kinases (MAPK) pathways and T-cell antigen receptor (TCR)-related pathways. The replication of HIV-1 latent infection could be reactivated by pH1N1 infection through TCR and apoptotic pathways. These data indicate that HIV-1 replication can be activated by pH1N1 virus in HIV-1-infected cells resulting in induction of cell death through apoptotic pathways.

SUBMITTER: Wang X 

PROVIDER: S-EPMC4776188 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells.

Wang Xue X   Tan Jiying J   Biswas Santanu S   Zhao Jiangqin J   Devadas Krishnakumar K   Ye Zhiping Z   Hewlett Indira I  

Viruses 20160202 2


Influenza virus infection has a significant impact on public health, since it is a major cause of morbidity and mortality. It is not well-known whether influenza virus infection affects cell death and human immunodeficiency virus (HIV)-1 replication in HIV-1-infected patients. Using a lymphoma cell line, Jurkat, we examined the in vitro effects of pandemic influenza A (H1N1) virus (pH1N1) infection on cell death and HIV-1 RNA production in infected cells. We found that pH1N1 infection increased  ...[more]

Similar Datasets

| S-EPMC3256529 | biostudies-other
| S-EPMC4106042 | biostudies-literature
| S-EPMC4417391 | biostudies-literature
| S-EPMC2890428 | biostudies-other
| S-EPMC3031580 | biostudies-literature
2013-04-17 | GSE46087 | GEO
2015-04-24 | MSV000079114 | MassIVE
| S-EPMC3322044 | biostudies-literature
| S-EPMC10791480 | biostudies-literature
| S-EPMC5942809 | biostudies-literature