Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4776331 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Li Jingjing J Ma Zhihai Z Shi Minyi M Malty Ramy H RH Aoki Hiroyuki H Minic Zoran Z Phanse Sadhna S Jin Ke K Wall Dennis P DP Zhang Zhaolei Z Urban Alexander E AE Hallmayer Joachim J Babu Mohan M Snyder Michael M
Cell systems 20151101 5
The prevalence of autism spectrum disorders (ASDs) is rapidly growing, yet its molecular basis is poorly understood. We used a systems approach in which ASD candidate genes were mapped onto the ubiquitous human protein complexes and the resulting complexes were characterized. The studies revealed the role of histone deacetylases (HDAC1/2) in regulating the expression of ASD orthologs in the embryonic mouse brain. Proteome-wide screens for the co-complexed subunits with HDAC1 and six other key AS ...[more]