Ontology highlight
ABSTRACT:
SUBMITTER: Beltran H
PROVIDER: S-EPMC4777652 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Beltran Himisha H Prandi Davide D Mosquera Juan Miguel JM Benelli Matteo M Puca Loredana L Cyrta Joanna J Marotz Clarisse C Giannopoulou Eugenia E Chakravarthi Balabhadrapatruni V S K BV Varambally Sooryanarayana S Tomlins Scott A SA Nanus David M DM Tagawa Scott T ST Van Allen Eliezer M EM Elemento Olivier O Sboner Andrea A Garraway Levi A LA Rubin Mark A MA Demichelis Francesca F
Nature medicine 20160208 3
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low to absent AR expression and often have neuroendocrine features. The etiology and molecular basis for this 'alternative' treatment-resistant cell state remain incompletely understood. Here, by analyzing whole-exome sequencing data of metastatic biopsies from patients, we observed substantial genomic overlap between castr ...[more]