Ontology highlight
ABSTRACT:
SUBMITTER: Beltran H
PROVIDER: S-EPMC7108892 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Beltran Himisha H Romanel Alessandro A Conteduca Vincenza V Casiraghi Nicola N Sigouros Michael M Franceschini Gian Marco GM Orlando Francesco F Fedrizzi Tarcisio T Ku Sheng-Yu SY Dann Emma E Alonso Alicia A Mosquera Juan Miguel JM Sboner Andrea A Xiang Jenny J Elemento Olivier O Nanus David M DM Tagawa Scott T ST Benelli Matteo M Demichelis Francesca F
The Journal of clinical investigation 20200401 4
Loss of androgen receptor (AR) signaling dependence occurs in approximately 15%-20% of advanced treatment-resistant prostate cancers, and this may manifest clinically as transformation from a prostate adenocarcinoma histology to a castration-resistant neuroendocrine prostate cancer (CRPC-NE). The diagnosis of CRPC-NE currently relies on a metastatic tumor biopsy, which is invasive for patients and sometimes challenging to diagnose due to morphologic heterogeneity. By studying whole-exome sequenc ...[more]