Ontology highlight
ABSTRACT:
SUBMITTER: Eckhard U
PROVIDER: S-EPMC4777984 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Eckhard Ulrich U Huesgen Pitter F PF Schilling Oliver O Bellac Caroline L CL Butler Georgina S GS Cox Jennifer H JH Dufour Antoine A Goebeler Verena V Kappelhoff Reinhild R Auf dem Keller Ulrich U Klein Theo T Lange Philipp F PF Marino Giada G Morrison Charlotte J CJ Prudova Anna A Rodriguez David D Starr Amanda E AE Wang Yili Y Overall Christopher M CM
Data in brief 20160222
The data described provide a comprehensive resource for the family-wide active site specificity portrayal of the human matrix metalloproteinase family. We used the high-throughput proteomic technique PICS (Proteomic Identification of protease Cleavage Sites) to comprehensively assay 9 different MMPs. We identified more than 4300 peptide cleavage sites, spanning both the prime and non-prime sides of the scissile peptide bond allowing detailed subsite cooperativity analysis. The proteomic cleavage ...[more]