Ontology highlight
ABSTRACT:
SUBMITTER: Morimoto A
PROVIDER: S-EPMC4778860 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Morimoto Ayako A Omachi Satoko S Osada Yasutaka Y Chambers James K JK Uchida Kazuyuki K Sanjoba Chizu C Matsumoto Yoshitsugu Y Goto Yasuyuki Y
PLoS neglected tropical diseases 20160304 3
Hemophagocytosis is a phenomenon in which macrophages phagocytose blood cells. There are reports on up-regulated hemophagocytosis in patients with infectious diseases including typhoid fever, tuberculosis, influenza and visceral leishmaniasis (VL). However, mechanisms of infection-associated hemophagocytosis remained elusive due to a lack of appropriate animal models. Here, we have established a mouse model of VL with hemophagocytosis. At 24 weeks after infection with 1 x 10(7) Leishmania donova ...[more]