PET Imaging of Tau Deposition in the Aging Human Brain.
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ABSTRACT:
SUBMITTER: Scholl M
PROVIDER: S-EPMC4779187 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
PET Imaging of Tau Deposition in the Aging Human Brain.
Schöll Michael M Lockhart Samuel N SN Schonhaut Daniel R DR O'Neil James P JP Janabi Mustafa M Ossenkoppele Rik R Baker Suzanne L SL Vogel Jacob W JW Faria Jamie J Schwimmer Henry D HD Rabinovici Gil D GD Jagust William J WJ
Neuron 20160301 5
Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent (18)F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory p ...[more]
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