Ontology highlight
ABSTRACT:
SUBMITTER: Solan JL
PROVIDER: S-EPMC4779375 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Solan Joell L JL Lampe Paul D PD
Seminars in cell & developmental biology 20151217
Gap junctions are highly ordered plasma membrane domains that are constantly assembled, remodeled and turned over due to the short half-life of connexins, the integral membrane proteins that form gap junctions. Connexin 43 (Cx43), by far the most widely expressed connexin, is phosphorylated at multiple serine residues in the cytoplasmic, C-terminal region allowing for exquisite cellular control over gap junctional communication. This is evident during epidermal wounding where spatiotemporal chan ...[more]