Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC4779412 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zhang Xiangmin X Damacharla Divyasri D Ma Danjun D Qi Yue Y Tagett Rebecca R Draghici Sorin S Kowluru Anjaneyulu A Yi Zhengping Z
Molecular and cellular endocrinology 20160109
Protein phosphatase 2A (PP2A) is one of the major serine/threonine phosphatases. We hypothesize that PP2A regulates signaling cascades in pancreatic β-cells in the context of glucose-stimulated insulin secretion (GSIS). Using co-immunoprecipitation (co-IP) and tandem mass spectrometry, we globally identified the protein interaction partners of the PP2A catalytic subunit (PP2Ac) in insulin-secreting pancreatic β-cells. Among the 514 identified PP2Ac interaction partners, 476 were novel. This repr ...[more]