Ontology highlight
ABSTRACT:
SUBMITTER: Zeng Y
PROVIDER: S-EPMC4779955 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Zeng Yaxue Y Yao Bing B Shin Jaehoon J Lin Li L Kim Namshik N Song Qifeng Q Liu Shuang S Su Yijing Y Guo Junjie U JU Huang Luoxiu L Wan Jun J Wu Hao H Qian Jiang J Cheng Xiaodong X Zhu Heng H Ming Guo-li GL Jin Peng P Song Hongjun H
Molecular cell 20151217 1
Lin28, a well-known RNA-binding protein, regulates diverse cellular properties. All physiological functions of Lin28A characterized so far have been attributed to its repression of let-7 miRNA biogenesis or modulation of mRNA translational efficiency. Here we show that Lin28A directly binds to a consensus DNA sequence in vitro and in mouse embryonic stem cells in vivo. ChIP-seq and RNA-seq reveal enrichment of Lin28A binding around transcription start sites and a positive correlation between its ...[more]