Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura T
PROVIDER: S-EPMC4780032 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nakamura Tamami T Hosoyama Tohru T Kawamura Daichi D Takeuchi Yuriko Y Tanaka Yuya Y Samura Makoto M Ueno Koji K Nishimoto Arata A Kurazumi Hiroshi H Suzuki Ryo R Ito Hiroshi H Sakata Kensuke K Mikamo Akihito A Li Tao-Sheng TS Hamano Kimikazu K
Scientific reports 20160307
Advanced age affects various tissue-specific stem cells and decreases their regenerative ability. We therefore examined whether aging affected the quantity and quality of cardiac stem cells using cells obtained from 26 patients of various ages (from 2 to 83 years old). We collected fresh right atria and cultured cardiosphere-derived cells (CDCs), which are a type of cardiac stem cell. Then we investigated growth rate, senescence, DNA damage, and the growth factor production of CDCs. All samples ...[more]