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MiR-429 functions as a tumor suppressor by targeting FSCN1 in gastric cancer cells.

ABSTRACT: It has been previously reported that the deregulation of microRNAs in gastric cancer (GC) was correlated with the progression and prognosis. miR-429, a member of the miR-200 family, was previously shown to play an important role in human carcinomas. Our study shows that miR-429 is significantly downregulated in GC tissues compared with matched nontumor tissues. Overexpression of miR-429 in GC cells suppressed cell proliferation. Fascin-1 (FSCN1) was identified as one of the targets of miR-429 and knockdown of FSCN1 mimics the function of miR-429 overexpression. In conclusion, miR-429 acts as a tumor suppressor by targeting FSCN1, suggesting that miR-429 and FSCN1 can both be potential therapeutic targets of GC.

SUBMITTER: Zhang M

PROVIDER: S-EPMC4780435 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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miR-429 functions as a tumor suppressor by targeting FSCN1 in gastric cancer cells.

Zhang Min M Dong Bing-Bin BB Lu Min M Zheng Mei-Juan MJ Chen He H Ding Jing-Zhen JZ Xu A-Man AM Xu Yuan-Hong YH

OncoTargets and therapy 20160303

It has been previously reported that the deregulation of microRNAs in gastric cancer (GC) was correlated with the progression and prognosis. miR-429, a member of the miR-200 family, was previously shown to play an important role in human carcinomas. Our study shows that miR-429 is significantly downregulated in GC tissues compared with matched nontumor tissues. Overexpression of miR-429 in GC cells suppressed cell proliferation. Fascin-1 (FSCN1) was identified as one of the targets of miR-429 an ...[more]

PMID: 27042104

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