Ontology highlight
ABSTRACT:
SUBMITTER: Sun F
PROVIDER: S-EPMC5943282 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Sun Feng F Yu Mengchao M Yu Jing J Liu Zhijian Z Zhou Xinyan X Liu Yanqing Y Ge Xiaolong X Gao Haidong H Li Mei M Jiang Xiaohong X Liu Song S Chen Xi X Guan Wenxian W
Cell death & disease 20180501 5
Gastric cancer (GC) is one of the most common malignant tumors and peritoneal metastasis is the primary cause for advanced GC's mortality. Protein-tyrosine phosphatase 1B (PTP1B) functions as an oncogene and involves in carcinogenesis and cancer dissemination. However, the function and regulation of PTP1B in GC remain poorly understood. In this study, we found that PTP1B was upregulated in GC tissues and overexpression of PTP1B in vitro promoted cell migration and prevented apoptosis. Then, we p ...[more]