Ontology highlight
ABSTRACT:
SUBMITTER: Reinardy HC
PROVIDER: S-EPMC4780559 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Reinardy H C HC Chapman J J Bodnar A G AG
Biology letters 20160201 2
Sea urchins are noted for the absence of neoplastic disease and represent a novel model to investigate cellular and systemic cancer protection mechanisms. Following intracoelomic injection of the DNA alkylating agent methyl methanesulfonate, DNA damage was detected in sea urchin cells and tissues (coelomocytes, muscle, oesophagus, ampullae and gonad) by the alkaline unwinding, fast micromethod. Gene expression analyses of the coelomocytes indicated upregulation of innate immune markers, includin ...[more]