Ontology highlight
ABSTRACT:
SUBMITTER: Sharma E
PROVIDER: S-EPMC4781813 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Sharma Eti E Pandey Saurabh S Gaur A K AK
3 Biotech 20160307 1
The 3-hydroxy-3-methyl glutaryl CoA reductase (HMGR) is the key enzyme of mevalonate pathway in plants. A partial genomic DNA fragment encoding HMGR conserved domain (denoted as AbHMGR) is isolated from Aconitum balfourii Stapf. It comprises 871 bp encoding 290 amino acids. In silico analysis reveals that it had extensive similarities to other plant HMGR gene. Domain analysis of AbHMGR showed two highly conserved NADPH and HMG CoA domains. Docking study predicted inhibitor, substrate and cofacto ...[more]