Ontology highlight
ABSTRACT:
SUBMITTER: Ye JZ
PROVIDER: S-EPMC478187 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Ye Jeffrey Zheng-Sheng JZ Hockemeyer Dirk D Krutchinsky Andrew N AN Loayza Diego D Hooper Sarah M SM Chait Brian T BT de Lange Titia T
Genes & development 20040701 14
Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to double-stranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded telomeric DNA-binding protein necessary for cis-inhibition of telomerase. By mass spectrometry, we have identified a new telomeric protein, which we have named POT1-interacting protein 1 (PIP1). PIP1 bound both POT1 and the TRF1-interacting factor TIN2 and could tether POT1 to the TRF1 complex. Reduction of PIP1 or POT1 l ...[more]