Ontology highlight
ABSTRACT:
SUBMITTER: Abdelkhalek HB
PROVIDER: S-EPMC478193 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Abdelkhalek Hanaa Ben HB Beckers Anja A Schuster-Gossler Karin K Pavlova Maria N MN Burkhardt Hannelore H Lickert Heiko H Rossant Janet J Reinhardt Richard R Schalkwyk Leonard C LC Müller Ines I Herrmann Bernhard G BG Ceolin Marcelo M Rivera-Pomar Rolando R Gossler Achim A
Genes & development 20040701 14
The floating head (flh) gene in zebrafish encodes a homeodomain protein, which is essential for notochord formation along the entire body axis. flh orthologs, termed Not genes, have been isolated from chick and Xenopus, but no mammalian ortholog has yet been identified. Truncate (tc) is an autosomal recessive mutation in mouse that specifically disrupts the development of the caudal notochord. Here, we demonstrate that truncate arose by a mutation in the mouse Not gene. The truncate allele (Nott ...[more]