Ontology highlight
ABSTRACT:
SUBMITTER: Janaszak-Jasiecka A
PROVIDER: S-EPMC4782134 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Janaszak-Jasiecka Anna A Bartoszewska Sylwia S Kochan Kinga K Piotrowski Arkadiusz A Kalinowski Leszek L Kamysz Wojciech W Ochocka Renata J RJ Bartoszewski Rafał R Collawn James F JF
Scientific reports 20160308
Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that allow cells to adapt and survive during hypoxia. Regulation of HIF1A and HIF2A mRNA is well characterized, whereas HIF3A mRNA regulation and function are less clear. Using RNA-Seq analysis of primary human umbilical vein endothelial cells, we found two isoforms of HIF3A were expressed, HIF3A2 and HIF3A3. Comparing HIF3A expression profiles to HIF1A mRNA during 48 hours of hypoxia revealed that HIF1A message peaked at 4 ...[more]