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Common Polymorphisms in IL-27 Genes May Contribute to Risk of Various Human Diseases in Asian Populations: A Meta-Analysis.

ABSTRACT: Genetic variations in the IL-27 gene have been proven to be associated with various types of human cancers and diseases. The purpose of the current study was to clarify the associations of the IL-27 rs153109 A>G and rs181206 T>C variants with human diseases using a meta-analysis study.A comprehensive electronic and manual search was carried out to find potential eligible studies. The effect size was represented by the unadjusted odds ratios (ORs). A 95% confidence interval (95%CI) was tested for the pooled OR using the Z test.A total of 17 case-control studies (cases=4185, healthy controls=4077) were included in our study. Our study showed that the carriers of the rs181206 T>C and rs153109 A>G polymorphism in the IL-27 gene have elevated risks of diseases in the allele model (rs181206 T>C: OR=0.76, 95%CI=0.69~0.84, P<0.001; rs153109 A>G: OR=0.85, 95%CI=0.76~0.94, P=0.002) and dominant model (rs181206 T>C: OR=0.77, 95%CI=0.69~0.87, P<0.001; rs153109 A>G: OR=0.84, 95%CI=0.71~0.99, P=0.033). Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).Our results indicate that the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases, especially of TB, UC, COPD, OC, and ITP.

SUBMITTER: Zhang YF

PROVIDER: S-EPMC4784550 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Common Polymorphisms in IL-27 Genes May Contribute to Risk of Various Human Diseases in Asian Populations: A Meta-Analysis.

Zhang Yun-Feng YF Zhao An-Di AD

Medical science monitor : international medical journal of experimental and clinical research 20160307

<h4>Background</h4>Genetic variations in the IL-27 gene have been proven to be associated with various types of human cancers and diseases. The purpose of the current study was to clarify the associations of the IL-27 rs153109 A>G and rs181206 T>C variants with human diseases using a meta-analysis study.<h4>Material/methods</h4>A comprehensive electronic and manual search was carried out to find potential eligible studies. The effect size was represented by the unadjusted odds ratios (ORs). A 95 ...[more]

PMID: 26950245

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Project description:Cancer incidence is dramatically increasing worldwide, therefore improved prediction and therapeutic methods are needed. Single nucleotide polymorphisms in cytokine genes may contribute to carcinogenesis. Interleukin (IL)?4 gene polymorphisms have been intensively studied with regard to their associations with cancer. However, the results of these previous studies remain inconclusive. The present study, therefore, aimed to conduct a meta?analysis of previously published studies in order to clarify the association of IL?4 with cancer risk. Eligible published articles were searched in Medline, PubMed, Embase and China National Knowledge Infrastructure databases up to March 2016. Odds ratios and 95% confidence intervals were used to identify potential associations between IL?4 genetic polymorphisms and the risk of cancer. A meta?analysis was then performed on 10,873 patients and 14,328 controls for IL?4 rs2243250 polymorphism, 3,970 patients and 5,686 controls for IL?4 rs2070874 polymorphism, and 1,896 patients and 2,526 controls for IL?4 rs79071878 polymorphism. A significant association with cancer risk was observed for rs2243250 and rs79071878 polymorphisms. In the subgroup analysis by cancer type, rs2243250 polymorphism was demonstrated to be associated with an increased risk of gastric cancer and breast cancer, rs2070874 polymorphism was correlated with leukemia and oral carcinoma, and rs79071878 polymorphism was relevant to bladder carcinoma risk. In the subgroup analysis by ethnicity, IL?4 rs2243250 polymorphism was demonstrated to be associated with cancer risk in both Caucasian and Asian populations, rs2070874 was associated with cancer risk in Asian populations, while rs79071878 polymorphism was associated with cancer risk in Caucasian populations. In conclusion, the present results suggested that the IL?4 rs2243250 and rs79071878 polymorphisms were associated with cancer susceptibility. Further subgroup analyses revealed that the effects of IL?4 gene polymorphisms on cancer risk may vary by cancer type and by ethnicity.

Dataset Information

Common Polymorphisms in IL-27 Genes May Contribute to Risk of Various Human Diseases in Asian Populations: A Meta-Analysis.

Publications

Common Polymorphisms in IL-27 Genes May Contribute to Risk of Various Human Diseases in Asian Populations: A Meta-Analysis.

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