Ontology highlight
ABSTRACT:
SUBMITTER: Carreira-Rosario A
PROVIDER: S-EPMC4785839 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Carreira-Rosario Arnaldo A Bhargava Varsha V Hillebrand Jens J Kollipara Rahul K RK Ramaswami Mani M Buszczak Michael M
Developmental cell 20160301 5
RNA-binding Fox (Rbfox) proteins have well-established roles in regulating alternative splicing, but specific Rbfox isoforms lack nuclear localization signals and accumulate in the cytoplasm. The potential splicing-independent functions of these proteins remain unknown. Here we demonstrate that cytoplasmic Drosophila Rbfox1 regulates germ cell development and represses the translation of mRNAs containing (U)GCAUG elements within their 3'UTRs. During germline cyst differentiation, Rbfox1 targets ...[more]