Ontology highlight
ABSTRACT:
SUBMITTER: Grebe KM
PROVIDER: S-EPMC478585 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Grebe Kristie M KM Clarke Raedun L RL Potter Terry A TA
Proceedings of the National Academy of Sciences of the United States of America 20040701 28
Thymocytes that are not positively selected are said to undergo "death by neglect." We have found that ligation of CD8, either by antibodies or MHC class I molecules, induces apoptosis of CD4(+)CD8+ double-positive (DP) thymocytes. The susceptibility of thymocytes to CD8-mediated apoptosis is developmentally regulated and confined to a subpopulation of DP thymocytes. Stimulation through CD3 protects thymocytes from CD8-mediated apoptosis. We suggest that during thymocyte development, binding of ...[more]