Ontology highlight
ABSTRACT:
SUBMITTER: Stadtmueller BM
PROVIDER: S-EPMC4786434 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Stadtmueller Beth M BM Huey-Tubman Kathryn E KE López Carlos J CJ Yang Zhongyu Z Hubbell Wayne L WL Bjorkman Pamela J PJ
eLife 20160304
As a first-line vertebrate immune defense, the polymeric immunoglobulin receptor (pIgR) transports polymeric IgA and IgM across epithelia to mucosal secretions, where the cleaved ectodomain (secretory component; SC) becomes a component of secretory antibodies, or when unliganded, binds and excludes bacteria. Here we report the 2.6Å crystal structure of unliganded human SC (hSC) and comparisons with a 1.7Å structure of teleost fish SC (tSC), an early pIgR ancestor. The hSC structure comprises fiv ...[more]