Ontology highlight
ABSTRACT:
SUBMITTER: Deng X
PROVIDER: S-EPMC4786711 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Deng Xiangyu X Qin Xiangjing X Chen Lei L Jia Qian Q Zhang Yonghui Y Zhang Zhiyong Z Lei Dongsheng D Ren Gang G Zhou Zhihong Z Wang Zhong Z Li Qing Q Xie Wei W
The Journal of biological chemistry 20160121 11
Glycyl-tRNA synthetase (GlyRS) is the enzyme that covalently links glycine to cognate tRNA for translation. It is of great research interest because of its nonconserved quaternary structures, unique species-specific aminoacylation properties, and noncanonical functions in neurological diseases, but none of these is fully understood. We report two crystal structures of human GlyRS variants, in the free form and in complex with tRNA(Gly) respectively, and reveal new aspects of the glycylation mech ...[more]