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Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp³)-H bonds.

ABSTRACT: The first nickel catalyzed deprotonative cross coupling between C(sp³)-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.

SUBMITTER: Fernandez-Salas JA

PROVIDER: S-EPMC4786957 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp3)-H bonds.

Fernández-Salas José A JA Marelli Enrico E Nolan Steven P SP

Chemical science 20150622 8

The first nickel catalyzed deprotonative cross coupling between C(sp3)-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds. ...[more]

PMID: 27019690

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