Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC6771714 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Li Wu W Liu Weiping W Leonard David K DK Rabeah Jabor J Junge Kathrin K Brückner Angelika A Beller Matthias M
Angewandte Chemie (International ed. in English) 20190701 31
The selective cleavage of thermodynamically stable C(sp<sup>3</sup> )-C(sp<sup>3</sup> ) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for C<sub>α</sub> -C<sub>β</sub> bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general ...[more]