Ontology highlight
ABSTRACT:
SUBMITTER: Sidman RL
PROVIDER: S-EPMC4787616 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Sidman Richard L RL Li Jianxue J Lawrence Matthew M Hu Wenzheng W Musso Gary F GF Giordano Ricardo J RJ Cardó-Vila Marina M Pasqualini Renata R Arap Wadih W
Science translational medicine 20151001 309
Blood vessel growth from preexisting vessels (angiogenesis) underlies many severe diseases including major blinding retinal diseases such as retinopathy of prematurity (ROP) and aged macular degeneration (AMD). This observation has driven development of antibody inhibitors that block a central factor in AMD, vascular endothelial growth factor (VEGF), from binding to its receptors VEGFR-1 and mainly VEGFR-2. However, some patients are insensitive to current anti-VEGF drugs or develop resistance, ...[more]